Determination of Migration Amounts of N-nitrosamine Substance in Silicone Pacifiers for Infants and young children and Analysis of Their Exposure Risks |
Received:March 27, 2023 Revised:March 27, 2023 |
DOI:10.12136/j.issn.1000-890X.2025.03.0220 |
Key Words: silicone pacifiers for infants and young children;N-nitrosamines substances;oral exposure mathematical model;simulating artificial saliva migration;GC-MS |
Author Name | Affiliation | E-mail | CHEN Dewen* | 杭州职业技术学院 | 42030692@qq.com | GONG Xudong | 义乌市产品(商品)质量检验研究院 | | ZHU Binchao | 义乌市产品(商品)质量检验研究院 | | WANG Zhenglin | 义乌市产品(商品)质量检验研究院 | | WU Min | 杭州职业技术学院 | |
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Abstract: |
A method for determining the migration amounts of 12 N-nitrosamine substances in silicone pacifiers for infants and young children,the oral exposure mathematical model was used to assess the exposure risk of N-nitrosamine substances in pacifiers.After simulating artificial saliva migration and extraction of pacifier samples,extracting N-nitrosamine substances used dichloromethane as a solvent,N-nitrosamine substances were analyzed using gas chromatography-mass spectrometry(GC-MS).The results showed that the quantification limits for the detecting the 12 N-nitrosamines substances in the mixed standard solution were 0.027~0.031 mg·L-1,with recovery rates of 86.9%~120.0% and relative standard deviations of 4.25%~8.31%.The N-nitrosamines substances with the highest content and occurring frequenly in pacifiers were N-nitrosobenzylamine and N-nitroso-N-methylaniline,respectively.According to the oral exposure mathematical model calculation,the daily intake of N-nitrosamines substances by infants and young children through contacting pacifier was significantly below the tolerable daily intake levels. |
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