| Film Thickness Measurement of Coated Rubber Closure by SEM |
| Received:March 13, 2018 Revised:March 13, 2018 |
| DOI： |
| Key Words: film coated rubber closure；film thickness；film uniformity；scanning electron microscope |
| Author Name | Affiliation | E-mail | | yangmingzhen* | ZHENGZHOU AOXIANG PHARMACEUTICAL PACKING CO.,LTD | 454577036@qq.com | | liuhaihong | 郑州翱翔医药科技股份有限公司 | |
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| Abstract: |
| The film thickness of polythene tetrafluoroethylene（ETFE） film coated brominated butyl rubber closure used for sealing sterile powder for injection was tested by scanning electron microscope（SEM），and the film thickness and film uniformity in different parts of rubber closure were investigated.The results showed that the ETFE film was compact，and well covered with the rubber closure matrix.The film thickness could be visually readout by using the scale of SEM.Film thickness at all testing positions were greater than 30 μm，and the film uniformity was good.In conclusion，film thickness in different parts of film coated rubber closure could be measured accurately by SEM，and it could objectively reflect the film uniformity. |
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