| 婴幼儿用硅橡胶奶嘴中N-亚硝胺类物质迁移量的测定及其暴露风险分析 |
| Determination of Migration Amounts of N-nitrosamine Substance in Silicone Pacifiers for Infants and young children and Analysis of Their Exposure Risks |
| 投稿时间：2023-03-27 修订日期：2023-03-27 |
| DOI：10.12136/j.issn.1000-890X.2025.03.0220 |
| 中文关键词: 婴幼儿用硅橡胶奶嘴 N-亚硝胺类物质 经口暴露量数学模型 模拟人工唾液迁移 气相色谱-质谱 |
| 英文关键词: silicone pacifiers for infants and young children N-nitrosamines substances oral exposure mathematical model simulating artificial saliva migration GC-MS |
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| 中文摘要: |
| 建立婴幼儿用硅橡胶奶嘴中12种N-亚硝胺类物质迁移量的测定方法，采用经口暴露量数学模型对奶嘴中N-亚硝胺类物质进行暴露风险评估。奶嘴样品经模拟人工唾液迁移浸提后，以二氯甲烷为溶剂萃取N-亚硝胺类物质，采用气相色谱-质谱（GC-MS）联用仪对N-亚硝胺类物质进行分析。结果表明：12种N-亚硝胺类物质在混合标准溶液中检出的定量限为0.027～0.031 mg·L-1，回收率为86.9%～120.0%，相对标准偏差为4.25%～8.31%；奶嘴中含量和出现频率最高的N-亚硝胺类物质分别为N-亚硝基联苄基胺和N-亚硝基-N-甲基苯胺；通过经口暴露量数学模型计算得出，婴幼儿每日通过接触奶嘴摄入的N-亚硝胺类物质量远小于每日耐受摄入量。 |
| 英文摘要: |
| A method for determining the migration amounts of 12 N-nitrosamine substances in silicone pacifiers for infants and young children，the oral exposure mathematical model was used to assess the exposure risk of N-nitrosamine substances in pacifiers.After simulating artificial saliva migration and extraction of pacifier samples，extracting N-nitrosamine substances used dichloromethane as a solvent，N-nitrosamine substances were analyzed using gas chromatography-mass spectrometry（GC-MS）.The results showed that the quantification limits for the detecting the 12 N-nitrosamines substances in the mixed standard solution were 0.027～0.031 mg·L-1，with recovery rates of 86.9%～120.0% and relative standard deviations of 4.25%～8.31%.The N-nitrosamines substances with the highest content and occurring frequenly in pacifiers were N-nitrosobenzylamine and N-nitroso-N-methylaniline，respectively.According to the oral exposure mathematical model calculation，the daily intake of N-nitrosamines substances by infants and young children through contacting pacifier was significantly below the tolerable daily intake levels. |
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