| Study on Cytotoxicity of Medicinal Polyisoprene Rubber |
| Received:May 25, 2020 Revised:May 25, 2020 |
| DOI：10.12136/j.issn.1000-890X.2021.02.0134 |
| Key Words: polyisoprene rubber；sodium chloride injection；purified water；extraction；microscope；tetrazolium salt colorimetry；cytotoxicity |
| Author Name | Affiliation | E-mail | | LIU Haihong* | Zhengzhou University | bestlhh@126.com | | CUI Zhe | 1.Zhengzhou University
2.Henan Key Laboratory of Advanced Nylon Materials and Applications | | | FU Peng | 1.Zhengzhou University
2.Henan Key Laboratory of Advanced Nylon Materials and Applications | |
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| Abstract: |
| Medicinal polyisoprene rubber（IR0307 and IR80） synthesized by two different catalytic systems were used as the research object，when sodium chloride injection with mass fraction of 0.9% and purified water were used as extraction media respectively，IR0307 and IR80 were extracted under two extraction conditions，such as extraction at 121℃ for 60 min in autoclave or extraction at 37 ℃ for 24 h in close-container.The cytotoxicity of IR0307 and IR80 were determined by microscopic observation and tetrazolium salt colorimetry，and the cytotoxicity reaction grade of IR0307 and IR80 under different extraction conditions were analyzed.In medical polyisoprene rubber，it was suggested to control the residual amount of catalyst and the content and types of impurities and metal ions，and use clean non-pollutiong anti-aging agent and stabilizer. |
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